Detailed Abstract
[Liver Oral Presentation 2 - Liver (Transplantation)]
[LV OP 2-7] IMPACT OF RADIATION THERAPY ON BILIARY COMPLICATIONS IN LIVER TRANSPLANTA HEPATOCELLULAR CARCINTION RECIPIENTS WITHOMA: A PROPENSITY SCORE-MATCHED ANALYSIS
Min-Ha CHOI 1, Sang-Hon KIM 1, Shin HWANG 1, Chul-Soo AHN 1, Deok-Bog MOON 1, Tae-Yong HA 1, Gi-Won SONG 1, Gil-Chun PARK 1, Ki-Hun KIM 1, Woo-Hyoung KANG 1, Young-In YOON 1, Byeong-Gon NAH 1, Sung-Min KIM 1, Sung-Gyu LEE 1, Dong-Hwan JUNG 1
1 Division of Hepatobiliary Surgery And Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan, Korea
Background : The role of radiation therapy (RT) in managing hepatocellular carcinoma (HCC) patients has significantly expanded. Therefore, the use of radiation therapy for pre-transplantation has also increased these days. However, its impact on post-transplant outcomes, particularly biliary complications, is not well defined This study aims to evaluate the effect of RT on biliary complications in LT recipients with HCC, utilizing propensity score-matching method for analysis.
Methods : A retrospective study was conducted on 1,008 HCC patients underwent LT between January 2018 and December 2023. Patients were classified into RT and non-RT groups. Propensity score matching was performed to ensure comparability. As the primary outcome, biliary complications were assessed. Logistic regression method was employed to analyze risk factors.
Results : RT was associated with an increased risk of biliary complications in both unmatched and matched analyses, particularly in biliary stricture(p= 0.005). Logistic regression analysis identified RT as an independent risk factor for biliary complications, with the unmatched cohort showing an OR of 1.642 (p = 0.033) and the matched cohort demonstrating an OR of 1.960 (p = 0.015). Other factors like separated multiple bile duct anastomosis (p = 0.019) and dual LDLT(Living donor liver transplantation) (p = 0.004) are also significant risk factor of bile duct complication.
Conclusions : RT in LT recipients with HCC is associated with a higher risk of biliary complications. Also, separated multiple bile duct anastomosis and dual LDLT can affect post-transplantation outcome. Future prospective studies are necessary to optimize RT protocols and improve outcomes in this population.
Methods : A retrospective study was conducted on 1,008 HCC patients underwent LT between January 2018 and December 2023. Patients were classified into RT and non-RT groups. Propensity score matching was performed to ensure comparability. As the primary outcome, biliary complications were assessed. Logistic regression method was employed to analyze risk factors.
Results : RT was associated with an increased risk of biliary complications in both unmatched and matched analyses, particularly in biliary stricture(p= 0.005). Logistic regression analysis identified RT as an independent risk factor for biliary complications, with the unmatched cohort showing an OR of 1.642 (p = 0.033) and the matched cohort demonstrating an OR of 1.960 (p = 0.015). Other factors like separated multiple bile duct anastomosis (p = 0.019) and dual LDLT(Living donor liver transplantation) (p = 0.004) are also significant risk factor of bile duct complication.
Conclusions : RT in LT recipients with HCC is associated with a higher risk of biliary complications. Also, separated multiple bile duct anastomosis and dual LDLT can affect post-transplantation outcome. Future prospective studies are necessary to optimize RT protocols and improve outcomes in this population.
SESSION
Liver Oral Presentation 2
Room 3 3/27/2025 3:30 PM - 4:30 PM