Detailed Abstract
[Liver Oral Presentation 3 - Liver (Liver Disease/Surgery)]
[LV OP 3-2] PREDICTIVE VALUE OF THE BODY WEIGHT-ADJUSTED FUTURE LIVER REMNANT-TO-SPLEEN VOLUME RATIO IN POST-HEPATECTOMY LIVER FAILURE FOLLOWING HEMI-HEPATECTOMY
Hyung Hwan MOON 1, Hyung June KU 2, Seoyeong KU 2, Suyeon KIM 3, Young Il CHOI 1, Dong Hoon SHIN 1, Ji Hoon JO 1, Sang Hwa SONG 4, Yang Seok KOH 4, Namkee OH 5, Jinsoo RHU 5, Garam LEE 6, Wong Jong YANG 7, Junho SONG 8, Chol Min KANG 9
1 Surgery, Kosin University Gospel Hospital, Korea, 2 Chang Kee-Ryo Memorial Liver Institute, Kosin University Gospel Hospital, Korea, 3 Information Medicine, Asan Medical Center, University of Ulsan, Korea, 4 Surgery, Chonnam National University Hospital, Korea, 5 Surgery, Samsung Medical Center, Sungkyunkwan University, Korea, 6 College of Veterinary Medicine, Chonnam National University, Korea, 7 Computer Science, New York University, United States of America, 8 College of Medicine, Pennsylvania State University, United States of America, 9 Applied Biomedical Engineering, The Johns Hopkins University, United States of America
Background : Post-hepatectomy liver failure (PHLF) is a critical complication after hemi-hepatectomy. Accurate prediction is essential for improving surgical outcomes. This study aimed to investigate the predictive value of the body weight-adjusted future liver remnant-to-spleen volume ratio (FLR/SV/Wt ratio) for PHLF.
Methods : A retrospective analysis was conducted on 224 patients who underwent hemi-hepatectomy. Demographics, laboratory data, and volumetric measurements, including FLR, spleen volume (SV), and body weight-adjusted FLR/SV ratio (FLR/SV/Wt), were analyzed. Logistic regression and receiver operating characteristic (ROC) curve analyses evaluated predictive factors for PHLF.
Results : Among 224 patients, 32 (14.3%) experienced PHLF (ISGLS grade B/C). Patients with PHLF showed significantly lower FLR/SV/Wt ratios (4.11 vs. 7.78; p < 0.001). Logistic regression identified the FLR/SV/Wt ratio as an independent predictor of PHLF (OR: 0.59, 95% CI: 0.386–0.901; p = 0.015). ROC curve analysis revealed an AUC of 0.738 for FLR/SV/Wt, with an optimal cutoff value of 7.737, sensitivity of 96.9%, and specificity of 40.1%.
Conclusions : The FLR/SV/Wt ratio is a significant predictor of PHLF following hemi-hepatectomy. Preoperative assessment incorporating FLR/SV/Wt may improve risk stratification and guide surgical decision-making.
Methods : A retrospective analysis was conducted on 224 patients who underwent hemi-hepatectomy. Demographics, laboratory data, and volumetric measurements, including FLR, spleen volume (SV), and body weight-adjusted FLR/SV ratio (FLR/SV/Wt), were analyzed. Logistic regression and receiver operating characteristic (ROC) curve analyses evaluated predictive factors for PHLF.
Results : Among 224 patients, 32 (14.3%) experienced PHLF (ISGLS grade B/C). Patients with PHLF showed significantly lower FLR/SV/Wt ratios (4.11 vs. 7.78; p < 0.001). Logistic regression identified the FLR/SV/Wt ratio as an independent predictor of PHLF (OR: 0.59, 95% CI: 0.386–0.901; p = 0.015). ROC curve analysis revealed an AUC of 0.738 for FLR/SV/Wt, with an optimal cutoff value of 7.737, sensitivity of 96.9%, and specificity of 40.1%.
Conclusions : The FLR/SV/Wt ratio is a significant predictor of PHLF following hemi-hepatectomy. Preoperative assessment incorporating FLR/SV/Wt may improve risk stratification and guide surgical decision-making.
SESSION
Liver Oral Presentation 3
Room 4 3/27/2025 3:30 PM - 4:30 PM