Detailed Abstract
[Liver Oral Presentation 3 - Liver (Liver Disease/Surgery)]
[LV OP 3-6] MICROWAVE ABLATION VERSUS LIVER RESECTION FOR EARLY HEPATOCELLULAR CARCINOMA IN PATIENTS WITH BORDERLINE LIVER FUNCTION (MAVERL STUDY)
Charing CHONG 1, Eugene LO 1, Janet KUNG 1, Andrew FUNG 1, HT LOK 1, John WONG 1, Paul LAI 1, KF LEE 1, Kenneth CHOK 1
1 Division of Hepatobiliary And Pancreatic Surgery, Department of Surgery,, The Chinese University of Hong Kong, Hong Kong, China
Background : Studies comparing microwave ablation (MWA) and liver resection are lacking. Earlier propensity score matching study reported better survival by MWA in patients with borderline liver function. We propose a randomized controlled study to compare the treatment efficacy of microwave ablation to liver resection for hepatocellular carcinoma (HCC) in patients with borderline liver function.
Methods : This is a prospective randomized study. Patients with borderline liver function (as defined by Child's A and ALBI 2) and HCC amendable to both liver resection and MWA were randomized. Overall and disease-free survival were compared between the two groups. Other perioperative outcomes were also analyzed.
Results : From June 2018 to May 2021, 76 patients were randomized. MWA was associated with significantly shorter operation time, less blood loss, lower post-operative complication rate, and shorter hospital stay. There was no significant difference in overall survival between the two groups (p =. 318). However, MWA was associated with a shorter disease-free survival (p = .014).
Conclusions : Liver resection offered superior disease-free survival to MWA in HCC patients with borderline liver function.
Methods : This is a prospective randomized study. Patients with borderline liver function (as defined by Child's A and ALBI 2) and HCC amendable to both liver resection and MWA were randomized. Overall and disease-free survival were compared between the two groups. Other perioperative outcomes were also analyzed.
Results : From June 2018 to May 2021, 76 patients were randomized. MWA was associated with significantly shorter operation time, less blood loss, lower post-operative complication rate, and shorter hospital stay. There was no significant difference in overall survival between the two groups (p =. 318). However, MWA was associated with a shorter disease-free survival (p = .014).
Conclusions : Liver resection offered superior disease-free survival to MWA in HCC patients with borderline liver function.
SESSION
Liver Oral Presentation 3
Room 4 3/27/2025 3:30 PM - 4:30 PM