Background : Laparoscopic liver resection (LLR) is a recognized approach for hepatocellular carcinoma (HCC), offering reduced morbidity and faster recovery. Subsegmental resections in segment 8 are technically challenging due to its deep anatomical location and complex vascular anatomy. Indocyanine green (ICG) fluorescence imaging enhances precision in anatomical resections.

Methods : A 52-year-old male patient presented with a 3.0 cm tumor located in subsegment 8. Preoperative imaging, including dynamic CT, confirmed a well-defined lesion without vascular invasion or extrahepatic spread. The patient underwent laparoscopic subsegmentectomy of segment 8 with ICG fluorescence imaging for navigation. An indirect staining method was employed for precise demarcation of the targeted subsegment.

Results : The procedure was successfully completed in 205 minutes with an estimated blood loss of 200 mL. Postoperative recovery was uneventful, and the patient was discharged on postoperative day 6. At the 1-month follow-up, imaging showed no recurrence. No intraoperative or postoperative complications were recorded.

Conclusions : This case highlights the feasibility and safety of laparoscopic subsegmentectomy for segment 8 using ICG fluorescence imaging. The enhanced visualization provided by ICG facilitates precise anatomical resections in challenging locations, contributing to favorable oncological and perioperative outcomes.