Detailed Abstract
[Poster Presentation 3 - Liver (Liver Disease/Surgery)]
[PP 3-6] THE IMPACT OF MULTIDISCIPLINARY TEAM APPROACH ON CLINICAL OUTCOMES IN HEPATOCELLULAR CARCINOMA: A PROPENSITY SCORE-MATCHED COHORT STUDY
Sang Hyuk PARK 1, YoungRok CHOI 1, Gayoung KIM 1, Min Kyoung KIM 1, Jiyoung KIM 1, Jae-Yoon KIM 1, Jeoung-Moo LEE 1, Suk Kyun HONG 1, Kwang-Woong LEE 1, Kyung-Suk SUH 1
1 Department of Surgery, Seoul National University Hospital, Korea
Background : Despite widespread implementation of multidisciplinary team (MDT) approach in hepatocellular carcinoma (HCC) management, evidence supporting its effectiveness remains limited. This study investigated the association between MDT-based treatment decisions and clinical outcomes in HCC patients.
Methods : In this retrospective study, propensity score matching was performed using age, sex, viral markers (HBV, HCV), and platelet count, yielding 304 matched pairs of MDT and non-MDT groups. Treatment adherence in the MDT group was classified as adherent (n=233), modified (n=56), or untreated (n=13). Primary endpoints were overall survival (OS) and disease-free survival (DFS).
Results : Median follow-up was 16 months for MDT group and 49 months for non-MDT group. After matching, baseline characteristics were well-balanced (all p>0.4). MDT group showed superior 3-year OS (94.9% vs 72.1%) and longer median survival (51.1 vs 14.7 months; p<0.001). Disease-free survival was comparable (3-year DFS: 50.9% vs 53.3%). In the MDT group, 76.6% of patients adhered to planned treatment, while 18.4% required modifications.
Conclusions : MDT approach was independently associated with improved overall survival in HCC patients, though not affecting disease-free survival. High treatment adherence demonstrates the feasibility of MDT-based decision-making in clinical practice.
Methods : In this retrospective study, propensity score matching was performed using age, sex, viral markers (HBV, HCV), and platelet count, yielding 304 matched pairs of MDT and non-MDT groups. Treatment adherence in the MDT group was classified as adherent (n=233), modified (n=56), or untreated (n=13). Primary endpoints were overall survival (OS) and disease-free survival (DFS).
Results : Median follow-up was 16 months for MDT group and 49 months for non-MDT group. After matching, baseline characteristics were well-balanced (all p>0.4). MDT group showed superior 3-year OS (94.9% vs 72.1%) and longer median survival (51.1 vs 14.7 months; p<0.001). Disease-free survival was comparable (3-year DFS: 50.9% vs 53.3%). In the MDT group, 76.6% of patients adhered to planned treatment, while 18.4% required modifications.
Conclusions : MDT approach was independently associated with improved overall survival in HCC patients, though not affecting disease-free survival. High treatment adherence demonstrates the feasibility of MDT-based decision-making in clinical practice.
SESSION
Poster Presentation 3
Exhibition Hall 3/27/2025 2:50 PM - 3:30 PM