Detailed Abstract
[Poster Presentation 11 - Biliary & Pancreas (Biliary Disease/Surgery)]
[PP 11-7] COMPARISON OF CLINICAL OUTCOMES OF TYPE 1 INTRADUCTAL PAPILLARY NEOPLASM OF BILE DUCT VERSUS TYPE 2 INTRADUCTAL PAPILLARY NEOPLASM OF BILE DUCT AFTER SURGICAL RESECTION
Yunghun YOU 1, In Woong HAN 2, Sang Hyun SHIN 2, So-Jeong YOON 2, Kee-Taek JANG 3, Jin Seok HEO 2
1 Surgery, Naen Hospital, Korea, 2 Surgery, Samsung Medical Center, Sungkyunkwan University, Korea, 3 Pathology And Translational Genomics, Samsung Medical Center, Sungkyunkwan University, Korea
Background : The purpose of this study is to find out whether there are differences in clinicopathological characteristics and oncological outcomes between subgroups (invasive type 1 IPNB and invasive type 2 IPNB). There is little investigation of oncologic outcomes according to type of invasive IPNB, which has the potential to cause recurrence.
Methods : From 2006 to 2018, consecutive 85 patients who were underwent surgical resection for IPNB. Type 1 IPNB was defined as IPNB with a well-organized papillary growth pattern and composed of a homogenous, regular lining epithelium and thin fibrovascular stalk. Type 2 IPNB was defined as IPNB with an irregular branching growth pattern and consisting of complex, irregular lining epithelium and thin to thick fibrovascular stalk.
Results : Among the total 85 cases of IPNB, there were 36 cases of invasive type 1 IPNB and 34 cases of invasive type 2 IPNB. Marginally significant difference in 5-year DFS was observed between the invasive type 1 IPNB and invasive type 2 IPNB (86.1 % vs 66.0 %, p = 0.085). In a multivariate analysis, the risk factor affecting recurrence were CA 19-9≥14 U/ml (p = 0.006) and invasion beyond ductal wall (p = 0.001).
Conclusions : Conclusively, there was marginally significant difference in 5-year DFS between invasive type 1 IPNB and invasive type 2 IPNB. Given these, it seems necessary to apply different follow-up duration and strategies depending on the type of IPNB.
Methods : From 2006 to 2018, consecutive 85 patients who were underwent surgical resection for IPNB. Type 1 IPNB was defined as IPNB with a well-organized papillary growth pattern and composed of a homogenous, regular lining epithelium and thin fibrovascular stalk. Type 2 IPNB was defined as IPNB with an irregular branching growth pattern and consisting of complex, irregular lining epithelium and thin to thick fibrovascular stalk.
Results : Among the total 85 cases of IPNB, there were 36 cases of invasive type 1 IPNB and 34 cases of invasive type 2 IPNB. Marginally significant difference in 5-year DFS was observed between the invasive type 1 IPNB and invasive type 2 IPNB (86.1 % vs 66.0 %, p = 0.085). In a multivariate analysis, the risk factor affecting recurrence were CA 19-9≥14 U/ml (p = 0.006) and invasion beyond ductal wall (p = 0.001).
Conclusions : Conclusively, there was marginally significant difference in 5-year DFS between invasive type 1 IPNB and invasive type 2 IPNB. Given these, it seems necessary to apply different follow-up duration and strategies depending on the type of IPNB.
SESSION
Poster Presentation 11
Exhibition Hall 3/28/2025 2:20 PM - 3:00 PM